Madhavan Rajan


MD MS FRCS Edin. FRCS Glas. FRCOphth

Professor Rajan is a clinical academic and ophthalmic surgeon based in Cambridge with expertise in management of corneal and cataract disorders and research interest in advanced surgical techniques and treatment cure for corneal blindness.

Present appointments

1. Consultant Ophthalmic Surgeon
Clinical lead – cornea and cataract service
Addenbrooke’s Hospital,
Cambridge University Hospitals,
2. Visiting Professor of Ophthalmic and Visual Sciences
Vision and Eye Research Unit (VERU),
Anglia Ruskin University,
Cambridge Rajan


3. Regional representative – East of England
Ocular Transplant Tissue Advisory Group (OTAG),
NHS – Blood & transplant, UK
4. Past Council member of UKISCRS – UK and Ireland Society of Cataract and Refractive Surgeons, UK.


5. Trustee and Chariman of Ophthalmic Alumni
Cambridge Eye Trust, Cambridge, UK.

Profile of Madhavan Rajan outside CambridgeSpire Hospital


  • FRCOphth, London
  • MD, University of London
  • MRCOphth, London
  • FRCS Glasg. (Ophthalmology)
  • FRCS Ed (Ophthalmology)
  • MS (Ophthalmology)
  • MBBS

Private Secretary

Ms Julie Wright
PA to Professor Madhavan Rajan
Spire Cambridge Lea Hospital
30, New Road
Impington, Cambridge
CB24 9EL

Tel: 01223 266 913
Fax: 01223 266 958

Julie Wright Profile Picture outside CambridgeSpire Hospital

Clinical Experience

Madhavan Rajan qualified in 1994 and underwent specialist ophthalmic training in London and has 18 years experience in ophthalmology. His interest in cataract, cornea and refractive surgery led to a research fellowship in laser refractive surgery at St Thomas’ Hospital, London culminating in a MD degree at the University of London. Subsequently, he spent 2 years as corneal, refractive and external eye diseases fellow at Moorfield’s Eye Hospital, London.

He was appointed consultant ophthalmic surgeon in 2007 and he is clinical lead of cornea and cataract service at Addenbrooke’s Hospital Cambridge and principal supervisor for the corneal fellowship programme. He was appointed as Professor of ophthalmic and Visual Sciences to Anglia Ruskin University, Cambridge in 2010. At the Vision and Eye Research Unit (VERU), he leads a corneal research team with basic science researchers and PhD studentships focused on corneal transplant research, corneal therapeutics, corneal stem cells and advanced intraocular lenses and has several publications in peer reviewed literature. Professor Rajan and his team had recently developed a novel endothelial keratoplasty  technique termed Microthin DSAEK with improved patient outcomes, that won the NHS Health enterprise Innovation award.

Mr Rajan is a keen sportsman, plays tennis and enjoys his rambling weekends in the Lakes, Dales and the Peaks. He highly values his time with family and is blessed with four children

Clinical interests and expertise

Cataract and Refractive Surgery

  • Microincisional cataract surgery
  • Refractive lens exchange
  • Refractive surgery and Presbyopia surgery
  • Premium Intraocular lenses – Toric and Multifocal IOLs

Cornea and External eye diseases

  • Corneal transplantation – Endothelial keratoplasty / Anterior lamellar keratoplasty
  • Kerataconus and corneal cross linking treatment
  • Dry eyes and ocular surface reconstruction surgery
  • Corneal infections
  • Immune mediated ocular surface disorders

Supervisory Role

Principle supervisor for two corneal and cataract fellows at Addenbrooke’s and undertake educational supervisory role for specialist ophthalmic trainees in the East of England and a PhD studentship at Anglia Ruskin University.

Professional Membership: General Medical Council, The Royal College of Ophthalmologists, London, UK and Ireland Cataract and Refractive Surgeons Society, European Cociety of Cataract and Refractive Surgeons, American Society of Cataract and Refractive Surgeons, UK Bowman corneal club member, British Refractive Surgeons society.

Research interests & expertise

  • Isolation and ex vivo culture of corneal endothelial cell precursors
  • In vitro human corneal model
  • Development of corneal drug delivery device
  • Temporal characteristics of endothelial graft thickness and visual recovery in manual and automated corneal endothelial keratoplasty
  • Developing strategies to optimize visual outcome in corneal transplantation
  • Advanced IOL technology


Visiting consultant to Lifeline express cataract charity in China

Children’s charity in UK & Abroad

Trustee to Cambridge Eye Trust Charity, Cambridge

Recent and selected peer reviewed publications

1: Voyatzis G, Roberts HW, Keenan J, Rajan MS. Cambridgeshire cataract shared
care model: community optometrist-delivered postoperative discharge scheme. Br J
Ophthalmol. 2014 Feb 10. doi: 10.1136/bjophthalmol-2013-304636. [Epub ahead of
print] PubMed PMID: 24515987.

2: Rajan MS. Surgical strategies to improve visual outcomes in corneal
transplantation. Eye (Lond). 2014 Feb;28(2):196-201. doi: 10.1038/eye.2013.279.
Epub 2014 Jan 3. PubMed PMID: 24384964.

3: Thomas PB, Mukherjee AN, O’Donovan D, Rajan MS. Preconditioned donor corneal
thickness for microthin endothelial keratoplasty. Cornea. 2013 Jul;32(7):e173-8.
doi: 10.1097/ICO.0b013e3182912fd2. PubMed PMID: 23665648.

4: Mukherjee A, Voyatzis G, Rajan MS. Reply to “Descemet stripping automated
endothelial keratoplasty: effect of intraoperative lenticule thickness on visual
outcome and endothelial cell density”. Cornea. 2013 Jan;32(1):108-9. doi:
10.1097/ICO.0b013e318263d08e. PubMed PMID: 23086362.

5: Voyatzis G, Mukherjee A, Rajan MS, Allen LE. Congenital unilateral corneal
anaesthesia with microphthalmos: a case report. Case Rep Ophthalmol Med.
2012;2012:703183. doi: 10.1155/2012/703183. Epub 2012 Mar 27. PubMed PMID:
22606500; PubMed Central PMCID: PMC3350140.

6: Hyatt AJ, Rajan MS, Burling K, Ellington MJ, Tassoni A, Martin KR. Release of
vancomycin and gentamicin from a contact lens versus a fibrin coating applied to
a contact lens. Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):1946-52. doi:
10.1167/iovs.11-8607. PubMed PMID: 22408014.

7: Voyatzis G, Pitalia A, Vize C, Rajan MS. Topical Bromfenac for Pseudophakic Cystoid Macular Edema. European Ophthalmic Review, 2012;6(4):230–5

8: Keenan TD, Jones MN, Rushton S, Carley FM; National Health Service Blood and
Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists (Ocular
Tissue Advisory Group Audit Study 8). Trends in the indications for corneal graft
surgery in the United Kingdom: 1999 through 2009. Arch Ophthalmol. 2012
May;130(5):621-8. doi: 10.1001/archophthalmol.2011.2585. PubMed PMID: 22652847.

9: Hayes S, Boote C, Kamma-Lorger CS, Rajan MS, Harris J, Dooley E, Hawksworth N,
Hiller J, Terill NJ, Hafezi F, Brahma AK, Quantock AJ, Meek KM. Riboflavin/UVA
collagen cross-linking-induced changes in normal and keratoconus corneal stroma.
PLoS One. 2011;6(8):e22405. doi: 10.1371/journal.pone.0022405. Epub 2011 Aug 5.
PubMed PMID: 21850225; PubMed Central PMCID: PMC3151245.

10: Logan S, Rajan M, Graham E, Johnson E, Klein J. A case of aspergillus
endophthalmitis in an immuncompetent woman: intra-ocular penetration of oral
voriconazole: a case report. Cases J. 2010 Jan 18;3:31. doi:
10.1186/1757-1626-3-31. PubMed PMID: 20205770; PubMed Central PMCID: PMC2822822.

11: Kashani S, Rajan M, Gartry D. Wavefront-guided retreatment after primary
wavefront-guided laser in situ keratomileusis in myopes and hyperopes: long-term
follow-up. Am J Ophthalmol. 2009 Mar;147(3):417-423.e2. doi:
10.1016/j.ajo.2008.09.017. Epub 2008 Dec 3. PubMed PMID: 19054497.

12: Tay E, Rajan M, Tuft S. Listeria monocytogenes sclerokeratitis: a case report
and literature review. Cornea. 2008 Sep;27(8):947-9. doi:
10.1097/ICO.0b013e31816c4078. PubMed PMID: 18724160.

13: O’Brart DP, Patsoura E, Jaycock P, Rajan M, Marshall J. Excimer laser
photorefractive keratectomy for hyperopia: 7.5-year follow-up. J Cataract Refract
Surg. 2005 Jun;31(6):1104-13. PubMed PMID: 16039483.

14: Daniel CS, Rajan MS, Saw VP, Claerhout I, Kestelyn P, Dart JK. Contact
lens-related Fusarium keratitis in London and Ghent. Eye (Lond). 2009
Feb;23(2):484-5. doi: 10.1038/eye.2008.188. Epub 2008 Jul 4. PubMed PMID:

15: Shortt AJ, Secker GA, Rajan MS, Meligonis G, Dart JK, Tuft SJ, Daniels JT. Ex
vivo expansion and transplantation of limbal epithelial stem cells.
Ophthalmology. 2008 Nov;115(11):1989-97. doi: 10.1016/j.ophtha.2008.04.039. Epub
2008 Jun 13. PubMed PMID: 18554721.

16: Tay E, Rajan MS, Saw VP, Dart JK. Dislocated intraocular lens into the
vitreous cavity after DSAEK. J Cataract Refract Surg. 2008 Mar;34(3):525-6. doi:
10.1016/j.jcrs.2007.11.016. PubMed PMID: 18299085.

17: Rajan MS, Bunce C, Tuft S. Interocular axial length difference and
age-related cataract. J Cataract Refract Surg. 2008 Jan;34(1):76-9. doi:
10.1016/j.jcrs.2007.08.023. PubMed PMID: 18165085.

18: Rajan MS, O’Brart D, Jaycock P, Marshall J. Effects of ablation diameter on
long-term refractive stability and corneal transparency after photorefractive
keratectomy. Ophthalmology. 2006 Oct;113(10):1798-806. PubMed PMID: 17011958.

19: Rajan MS, O’Brart DP, Patmore A, Marshall J. Cellular effects of mitomycin-C
on human corneas after photorefractive keratectomy. J Cataract Refract Surg. 2006
Oct;32(10):1741-7. PubMed PMID: 17010877.

20: Rajan MS, O’Brart DP, Patel P, Falcon MG, Marshall J. Topography-guided
customized laser-assisted subepithelial keratectomy for the treatment of
postkeratoplasty astigmatism. J Cataract Refract Surg. 2006 Jun;32(6):949-57.
PubMed PMID: 16814052.

21: Rajan MS, Pantelidis P, Tong CY, French GL, Graham EM, Stanford MR. Diagnosis
of Treponema pallidum in vitreous samples using real time polymerase chain
reaction. Br J Ophthalmol. 2006 May;90(5):647-8. PubMed PMID: 16622098; PubMed
Central PMCID: PMC1857041.

22: Rajan MS, Watters W, Patmore A, Marshall J. In vitro human corneal model to
investigate stromal epithelial interactions following refractive surgery. J
Cataract Refract Surg. 2005 Sep;31(9):1789-801. PubMed PMID: 16246786.

23: Jaycock PD, O’Brart DP, Rajan MS, Marshall J. 5-year follow-up of LASIK for
hyperopia. Ophthalmology. 2005 Feb;112(2):191-9. PubMed PMID: 15691550.

24: Rajan MS, Shafiei S, Mohrenfels CV, Patmore A, Lohmann C, Marshall J,
Hamberg-Nystrom H. Effect of exogenous keratinocyte growth factor on corneal
epithelial migration after photorefractive keratectomy. J Cataract Refract Surg.
2004 Oct;30(10):2200-6. PubMed PMID: 15474836.

25: O’Brart DP, Patsoura E, Jaycock P, Rajan M, Marshall J. Excimer laser
photorefractive keratectomy for hyperopia: 7.5-year follow-up. J Cataract Refract
Surg. 2005 Jun;31(6):1104-13. PubMed PMID: 16039483.

26: Rajan MS, Jaycock P, O’Brart D, Nystrom HH, Marshall J. A long-term study of
photorefractive keratectomy; 12-year follow-up. Ophthalmology. 2004
Oct;111(10):1813-24. PubMed PMID: 15465541.

27: Sobha S, Rajan MS, Jackson H. Choroidal neovascularization following
hyperopic LASIK surgery. Clin Experiment Ophthalmol. 2004 Aug;32(4):443-5. PubMed
PMID: 15281987.

28: Rajan MS, Syam P, Liu C. Systemic side effects of topical latanoprost. Eye
(Lond). 2003 Apr;17(3):442-4. PubMed PMID: 12724721.

29: Kielhorn I, Rajan MS, Tesha PM, Subryan VR, Bell JA. Clinical assessment of
the Zeiss IOLMaster. J Cataract Refract Surg. 2003 Mar;29(3):518-22. PubMed PMID:

30: Rajan MS, Bremner FD, Riordan-Eva P. Pupil perimetry in the diagnosis of
functional visual field loss. J R Soc Med. 2002 Oct;95(10):498-500. PubMed PMID:
12356970; PubMed Central PMCID: PMC1279175.

31: Rajan MS, Keilhorn I, Bell JA. Partial coherence laser interferometry vs
conventional ultrasound biometry in intraocular lens power calculations. Eye
(Lond). 2002 Sep;16(5):552-6. PubMed PMID: 12194067.

32: Barampouti F, Rajan M, Aclimandos W. Should active CMV retinitis in
non-immunocompromised newborn babies be treated? Br J Ophthalmol. 2002
Feb;86(2):248-9. PubMed PMID: 11815360; PubMed Central PMCID: PMC1771008.